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Genomic pathological study on tumor immunity by cross-organ approach

Recent studies have revealed that the surrounding immune cells play an important role in cancers that occur in various organs throughout the body. Complex genetic abnormalities are thought to be involved in this background. Conventional research has been conducted separately for each tumor, such as gastric cancer for stomach cancer and colorectal cancer for colorectal cancer. I thought and planned this research. In this research, we will use organs that have been removed by surgery, biopsy, or pathological autopsy so far, so there is no burden on the patient, and it will not affect future treatment policies. And there are no costs involved. This research has been reviewed by the Kanazawa University Human Genome/Gene Analysis Research Ethics Review Committee and approved by the Director of the Kanazawa University Pharmaceutical and Health Research Area.

1. Subject of research

Patients who underwent ovary, uterus, kidney, bladder, prostate, lung, stomach, large intestine, thyroid, liver, pancreas, brain, heart, and great vessel resection or biopsy at our hospital from 1970 to the present, If there are any bereaved families of patients who have undergone pathological autopsies who do not wish to participate in this study, please let us know. In that case, the data will not be used and will not affect future treatment at all. Also, if you would like to know if you are the subject of this research, we will investigate and answer.

2. Purpose of research

The purpose of this research is to understand the characteristics of tumors in various organs of the whole body and the status of immune reactions around them, and to clarify their relationships by methods such as immunohistochemistry and genome analysis.

3. Research methods

In this research, we will select some cases from the above (1. Research subjects) and use the remaining organs removed by biopsy, surgery, and pathological autopsy. At that time, personal information such as the patient's name will be deleted. After that, we will collect the necessary data and investigate the relationship with background genetic abnormalities of the tumor, the distribution and characteristics of immune cells, etc. Immunohistochemistry is used for protein expression and sequencing techniques are used for genetic analysis. Collected data may be presented at academic conferences or in papers, but personal information will not be made public.

4. Disclosure of analysis results

In principle, the results obtained in this study will not be disclosed to the patient or legally acceptable person.

5. About genetic counseling

If you would like to consult about diseases or genetic analysis research, we will introduce specialized staff in charge of counseling. In addition, we can provide the research plan of this research and materials on the research method upon request. Please feel free to contact the contact person listed at the end.

6. Study period

The period of this study is from July 19, 2022 to March 31, 2027, the approval date of Kanazawa University.

7. Types of specimens and information used in research

Specimen: Pathological tissue specimen extracted from a patient during biopsy, surgery, or pathological autopsy and stored. Information: Patient medical information, including information that can identify an individual patient, such as the results of pathological examinations.

8. Provision and publication of specimens and information to external parties

We will not provide or publish samples or information to external organizations or research institutes.

9. Anticipated Benefits and Disadvantages

This study is a data survey only, and there is no direct benefit to patients from participating in this study. Although the possibility of leakage of personal information is not negligible as a predicted disadvantage, we will pay close attention to the handling of data so that it will not be leaked to the outside.

10. Privacy protection

In this study, a numbered list will be created that corresponds to the patient's name, and only those numbers that do not contain personal information will be used to examine the data. This list will be handled separately from the data so that personal information will not be leaked when investigating the data. In addition, although the results obtained in this study may be published in academic societies and medical journals, your personal information will never be disclosed.

11. Burden of expenses associated with research participation and hospital visits

Participating in this study will not incur any costs or new visits just for the study.

12. Research organization

Daichi Maeda, Associate Professor, Molecular and Cellular Pathology, Kanazawa University School of Medicine, Kanazawa University Masafumi Horie, Assistant Professor, Molecular and Cellular Pathology, Kanazawa University School of Medicine, Kanazawa University Yukinobu Ito Takeshi Oyama, Department of Molecular and Cellular Pathology, Faculty of Health Sciences, Assistant Professor Hiroko Ikeda, Professor, Department of Diagnostic Pathology, Kanazawa University Hospital

13. Funding for this research and conflicts of interest

The person in charge of this research has no conflict of interest with companies, etc. in this research. The person in charge of this research has self-reported to the conflict of interest examination body based on the regulations of Kanazawa University, and has obtained its review and approval. Therefore, I will not compromise my professional judgment for personal gain in the conduct of this research.

14. Freedom to Not Participate in Research

If the patient or the patient's representative does not approve the use of the samples and information for the research, they will not be included in the research. Please let us know.

15. Obtaining materials such as research plans

If you would like to see materials such as the research plan for this research, or if you would like to see it, please contact the research contact and we will respond.

16. Contact point for research

If you want to know more detailed information about the contents of this research, such as words you don't understand, doubts, questions, whether you are the target of this research, etc., please do not hesitate to ask at any time.

Name of research institution: Medical School, Kanazawa University Medical School Research Director: Daichi Maeda
Personal information manager: Yuki Mitani (Molecular and Cellular Pathology, Graduate School of Medicine, Kanazawa University)
Inquiries: Daichi Maeda (Department of Molecular and Cellular Pathology, Graduate School of Medicine, Kanazawa University)
Address: 13-1 Takaramachi, Kanazawa
Phone: 076-265-2190 or 2192 [Direct]